Interventional Cardiology, 2017 (vol. 16), issue 4

Original articles

Plasma sCD163 levels in patients with ST-elevation myocardial infarction

Radek Pudil, Lucie Horáková, Ctirad Andrýs, Josef Šťásek

Interv Akut Kardiol. 2017;16(4):142-145 | DOI: 10.36290/kar.2017.023

Background: The ischemia/reperfusion process in the course of acute coronary syndrome with ST-segment elevation is associatedwith significant increase of immune system activation. CD163 molecule belongs to important parts of the scavenger system,which helps to eliminate hemoglobin-haptoglobin complex and has the potential to suppress reactive oxygen radicals production.Aim: The aim of our study was to assess sCD163 level in the course of STEMI.Patients and method: Plasma sDC163 level was assessed in a group of 29 patients (25 males, 4 females) of average age 64.5 let± 7.5 yrs. at the time of admission, at 24 hours and at 96 hours.Results: The...

Review articles

Cardiac implanted electronic device-related infective endocarditis

Jana Bínová, Miloš Kubánek, Kamil Sedláček, Lukáš Krýže, Josef Kautzner

Interv Akut Kardiol. 2017;16(4):146-150 | DOI: 10.36290/kar.2017.021

The use of cardiac implantable electronic devices has expanded dramatically over the past decade and infective endocarditis ofthese devices (CDRIE) is associated with high morbidity and mortality. 1 year mortality has not improve and remains at 25 %. Riskgroups are mainly older patients with multiple commorbidities. CDRIE occurs most often 6 month after implantation. Staphylococcalpredominate as the causative organism. Diagnosis of disease is not easy, clinical presentation is highly variable. Echocardiographyand blood cultures are the cornerstones of the diagnosis. CDRIE must be treated by prolonged antibiotic therapy and frequentlyrequires complete...

Case reports

A rare cause of acute myocardial infarction in a 20-year-old patient diagnosed with severe ketoacidosis

František Nehaj, Michal Mokáň, Juraj Sokol, Ľudovít Šutarík, František Kovář, Martin Janík, Marianna Kubašková, Peter Galajda, Marián Mokáň

Interv Akut Kardiol. 2017;16(4):152-155 | DOI: 10.36290/kar.2017.015

Cardiovascular diseases are the most common cause of the mortality in developed countries. The coronary artery disease is onthe first place as a cause of a death what represent seven million people every year and 12.8 % from all deaths in the world. Everysixth man and every seventh woman die of myocardial infarction (MI). Diabetes mellitus (DM) belongs to the most commonchronic diseases and cardiovascular diseases occur with this diagnose 4–8 times more often. The acute complications of DM arecaused by sudden metabolic decompensation, which can directly threaten the life of the patient. We present a case report of 20years old woman with juvenile...

Acute coronary syndrom as a rare trigger of Tako-tsubo cardiomyopathy

Lucia Sabolová

Interv Akut Kardiol. 2017;16(4):156-157 | DOI: 10.36290/kar.2017.022

Stress cardiomyopathy and myocardial infarction are generally regarded as mutually exclusive diagnoses. We report cases oftwo women with acute chest pain. Their echocardiogram and ventriculography were typical of stress cardiomyopathy, but alsothey had one acute occlusive or subocclusive coronary lesion and a highly significant rise in troponin (non typical for Tako-tsubocardiomyopathy). This is a rare case of concomitant myocardial infarction and stress cardiomyopathy, in which the acute coronarysyndrome itself may have been the stressor, given the absence of other identifiable causes.

Pharmacotherapy

Evolocumab for the treatment of familial hypercholesterolemia

Vladimír Bláha

Interv Akut Kardiol. 2017;16(4):158-164

Familial hypercholesterolaemia (FH) is the most common dominantly inherited monogenic disorder in human beings worldwide.Familial hypercholesterolaemia is caused by mutations in genes encoding key proteins involved in low density lipoproteincholesterol (LDL-C) metabolism, which leads to reduced cellular uptake of LDL cholesterol, increased plasma LDL cholesterolconcentrations, and premature development of cardiovascular disease. Despite the availability of reliable diagnostic criteria (highLDL-C levels, family history or premature CHD and hypercholesterolemia, cerebral/peripheral vascular disease, and the presenceof tendon xanthomata or presence of...