Interv Akut Kardiol. 2017;16(4):142-145 | DOI: 10.36290/kar.2017.023
Plasma sCD163 levels in patients with ST-elevation myocardial infarction
- 1 I. interní kardioangiologická klinika, LF UK a FN Hradec Králové
- 2 Ústav klinické imunologie a alergologie, LF UK a FN Hradec Králové
Background: The ischemia/reperfusion process in the course of acute coronary syndrome with ST-segment elevation is associatedwith significant increase of immune system activation. CD163 molecule belongs to important parts of the scavenger system,which helps to eliminate hemoglobin-haptoglobin complex and has the potential to suppress reactive oxygen radicals production.
Aim: The aim of our study was to assess sCD163 level in the course of STEMI.Patients and method: Plasma sDC163 level was assessed in a group of 29 patients (25 males, 4 females) of average age 64.5 let± 7.5 yrs. at the time of admission, at 24 hours and at 96 hours.
Results: The plasma sCD163 level was increasing during the time of observation [0h: 1770.5 (1451; 2096.25) μg/L vs. 1178 (1078;1265) μg/L, p < 0.001, 24h: 2063 (1589; 2453) vs. 1178 (1078;1265) μg/L, p < 0.001, 96h: 2116 (1924; 2458) vs. 1178 (1078; 1265) μg/L, p < 0.001]. Plasma sCD163 level was associated with leftventricle ejection fraction.
Conclusion: The study showed a potential significance of sCD163 assessment as a prognostic marker.
Keywords: ST-elevation myocardial infarction, humoral immunity, reperfusion, soluble CD163
Received: November 14, 2017; Accepted: December 14, 2017; Published: December 1, 2017 Show citation
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