Current position of GP IIb/IIIa inhibitors

Ivo Varvařovský

Interv Akut Kardiol. 2008;7(6):207-209  

Platelet polymorphisms and feasibility of monitoring of antiplatelets therapy results

Jan Kvasnička, Jaroslava Hájková, Petra Bobčíková

Interv Akut Kardiol. 2008;7(6):215-218  

The aim of study was to assess the frequencies of platelet polymorphisms which are connected with „aspirin resistance“ or/and variability of clopidogrel response in Czech population. The anonymous testing of 1,450 blood donors DNA by PCR using Light Cycler 480 (ROCHE) were used in finding of GP IIIa (HPA-1; rs5918), P2Y12 (H1/H2 haplotype; rs2046934) and COX-1 (-842A/G; rs10306114) polymorphisms frequencies. Results. The frequencies of GP IIIa (HPA1) were: 27.40 % heterozygotes, 3.66 % homozygotes and 68.94 % wild type homozygotes, frequencies of P2Y12 (H1/H2 haplotype) were 25.92 % heterozygotes, 2.63 %...

Difficulty of anticoagulant therapy in atrial fibrillation - interactions of warfarin with drugs and food

Kateřina Lefflerová

Interv Akut Kardiol. 2008;7(6):220-224  

Atrial fibrillation is the most common cardiac arrhythmia, which promotes trombus formation particularly in the left atrium and increases the overall risk of stroke five-fold. One of the main objectives of treating patients with atrial fibrillation is to prevent thrombo-embolism and reduce risk of stroke. Meta-analysis of large randomized trials showed risk reduction of 68 %, adjusted-dose oral anticoagulation is more effective than aspirin against stroke. The optimal intensity of oral anticoagulation in atrial fibrillation is the value of INR 2.0–2.5. Although effective, vitamin K antagonists have narrow therapeutic window, over-anticoagulation...

Catheter ablation of atrial fibrillation: potential complications of procedure and means of their prevention

Petr Peichl, Hanka Mlčochová, Robert Čihák, et al

Interv Akut Kardiol. 2008;7(6):226-229  

Catheter ablation of atrial fibrillation is a modern therapeutic method that effectively prevents arrhythmia recurrences. The procedure is, however, still associated with potentially severe complications, while some of them are specific only for this type of ablation. Our review lists the most important complications, means of their diagnosis, prevention and therapy. The most important complications comprise: cardiac tamponade, hemothorax, embolic events, pulmonary vein stenosis, atrio-esophageal fistula, phrenic nerve injury and regular atrial arrhythmias after ablation. The key role in prevention of these complications play the operator’s experiences...

Ventricular ectopy as a syndrome of a clinical asymptomatic severe coronary insufficiency

Milan Mikuš, Tereza Mikušová, Jindřich Černý, et al

Interv Akut Kardiol. 2008;7(6):231-234  

Two cases present patients with abruptly manifesting numerous ventricular ectopy, without stenocardia and dyspnea, and without overt structural affliction of the heart or symptoms of ischemia during bicycle ergometry stress test. Despite this, coronary arteriography revealed grave affliction of coronary arteries and follow-up revascularization resulted in elimination of ventricular ectopy. Thus the ventricular ectopic activity was the only syndrome of a severe coronary insufficiency leading up to its timely diagnostics and treatment.

ESC 2008, Munich

Stanislav Šimek

Interv Akut Kardiol. 2008;7(6):236-237