Interv Akut Kardiol. 2009;8(2):70-73

Strategy to reduce the risk of contrast-induced nephropathy in patients at moderate risk in Cardiocenter Třinec

Alexandra Vodzinská, Marian Branny, Jan Indrák, Jindřich Černý, Igor Nykl, Jaroslav Januška

Kardiocentrum Nemocnice Podlesí, Třinec

Intravenous administration of physiological saline solution before and after examination using contrast medium is effective in prevention

of contrast-induced nephropathy in high-risk patients.

Aim: to test effectiveness of the intravenous administration of the physiological saline solution in prevention of the contrast-induced

nephropathy in medium-risk patients to compare the effectivenesd of the physiological saline solution to the bicarbonate solution.

Methods: medium risk group of 118 patients undergoing coronary angiography or coronary angioplasty was tested. 71 patients were

randomly divided into two groups. The first group was given the physiological saline solution, while the second group was given the

bicarbonate solution. The results of renal function tests were compared to those from control group without any hydration (47 patiens).

All patients were checked for mineralogram and the renal functions after 3 and 30 days.

Results: Development of the contrast-induced nephropathy (CIN) was significantly influenced (p value < 0.01), by the entry level of creatinin

clearance, presence of diabetes mellitus and age. Statistically insignificant were the amount of contrast solution and sex.

Conclusion: The development of CIN was not significantly influenced using the intravenous hydration with the physiological saline

at medium-risk patients undergoing selective coronary angiography or coronary angioplasty. The statistically significant difference

between the hydration using the physiological saline and the bicarbonate has not been found.

Keywords: contrast-induced nephropathy, hydration, creatinin clearance.

Published: May 1, 2009  Show citation