Interv Akut Kardiol. 2007;6(2):47-49

In-stent thrombosis risk factors

Roman Kollros¹, Pavel Boček¹, Ivan Šubrt², František Šefrna¹

¹ I. interní klinika, FN Plzeň

² Ústav lékařské genetiky, LF UK a FN Plzeň

Background: Acute or subacute in-stent thrombosis (IST) is a rare, but frightened complication in patients treated with percutaneous coronary intervention (PCI). There are many factors influencing appearance of IST. Some are well known, but influence of the presence of polymorphism in prothrombotic genes is not clearly established – data from the studies concerning of this problem are unconsistent and controversial.

Aim: To assess importance of the presence of genetical abnormality (polymorphism in prothrombotic genes, i. m. Leiden mutation in gene for coagulation factor V, polymorphism in gene for prothrombin and in gene for MTHFR – methylene tetrahydrofolate reductase) for the incidence of IST.

Methods: We performed a retrospective analysis of the Faculty Hospital in Pilsen PCI computerized database and compare the group of patients (pts.) who suffered ST with those, who did not.

Results: 3784 pts. undervent succesfull coronary stent implantation between January 1, 2002 and September 30, 2005. IST occured 44× in 35 pts. (incidence of ST = 1,16 %) within 30 days of stent placement. We found a significant relation between the rate of ST and the level of CRP, fibrinogen and number of platelets in the time of first PCI, also the number of stents placed (stented lenght, respectively) was higher in pts. suffering IST. No significant differencies were found in the rate of polymorphism in prothrombotic genes between those suffering IST and common middle-european population. In-hospital and 30-days mortality were expressively higher in the group of IST.

Conclusion: Presence of polymorphism in prothrombotic genes appears not to be an independent risk factor for stent thrombosis.

Keywords: coronary thrombosis, stents, genetic polymorphism

Published: June 1, 2007  Show citation