Interv Akut Kardiol. 2005;4(2):115-118

THROMBOLYTIC TREATMENT OF ACUTE SUBMASSIVE PULMONARY EMBOLISM

Daniela Žáková
Interní oddělení, Nemocnice Ivančice

Acute pulmonary embolism is the third most common cardiovascular disease with very high mortality. The prognosis of acute pulmonary embolism is dependent on the degree of haemodynamic status of the patients. Risk factors include right ventricular dysfunction, elevated plasma levels of cardiac troponins and brain natriuretic peptide. Based on these factors we can identify a group of patients with higher recurrence rates of embolism and with higher mortality. According to some authors, the thrombolytic treatment in this group of patients is more effective than conventional heparin treatment, although there is no clear evidence and the approach must be individual. There use of thrombolytic treatment in a group of high risk patients with acute submassive pulmonary embolism is well documented.

Keywords: Key words: pulmonary embolism, right ventricular dysfunction, trombolysis.

Published: January 1, 2006  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Žáková D. THROMBOLYTIC TREATMENT OF ACUTE SUBMASSIVE PULMONARY EMBOLISM. Interv Akut Kardiol. 2005;4(2):115-118.
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. Gregor P, Widimský P, et al. Kardiologie, druhé, přepracované a rozšířené vydání. 1999; 321.
    2. Konstantinides S, Hasenfuss G. Acute cor pulmonale in pulmonary embolism. An Important prognostic factor and a critical parameter for the choice of the therapeutic Strategy. Internist 2004; 45(10): 1155-162. Go to original source... Go to PubMed...
    3. Task Force Report. Task Force on Pulmonary Embolism. Guidelines on diagnosis and management of acute pulmonary embolism. Eur Heart J 2000; 21: 1301-1336. Go to original source... Go to PubMed...
    4. Widimský J, Malý J. Doporučení pro diagnostiku a léčbu plicní embolie. Verze 2001. Cor Vasa 2001; 43: K158-184.
    5. Goldhaber SZ, Visani L, DeRosa M for ICOPER. Acute pulmonary embolism: clinical outcomes in the international Cooperative Pulmonary Embolism Registry(ICOPER). Lancet 1999; 353: 1386-1389. Go to original source... Go to PubMed...
    6. Kasper W, Konstantinides S, Geibel A, et al. Management strategie and determinants of outcome in acute major pulmonary embolism: results of a multicenter registry. J Am Coll Cardiol. 1997; 30: 1172-1173. Go to original source... Go to PubMed...
    7. Goldhaber SZ, Elliott CG. Acute Pulmonary Embolism: Part II: Risk Stratification, Treatement, and Prevention. Circulation 2003; 108: 2834-2838. Go to original source... Go to PubMed...
    8. Konstantinides S, Geibel A, Olschewski M, et al. Association between thrombolytic treatment and the prognosis of hemodynamically stable patiens with major pulmonary embolism: results of a multicenter registry. Circulation 1997; 96: 716-718. Go to original source... Go to PubMed...
    9. Widimský J. Stratifikace rizika akutní plicní embolie. Cor Vasa 2004; 46: 379-383.
    10. Franc P. Echokardiografie u akutní plicní embolie. Cor Vasa 2004; 46: 115-122.
    11. Grifoni S, Olivotto I, Cecschinz P, et al. Short-term clinical outcome of patiens with acute pulmonary embolism, normal blood pressure end echocardiographic right ventricular dysfunction. Circulation 2000; 101: 2817-2822. Go to original source... Go to PubMed...
    12. Konstantinides S, Geibel A, Olschewski M, et al. Importace od Cardiac Troponins I And T in Risk Stratification of Patiens With Acute Pulmonary Embolism. Circulation 2003; 106: 1263-1268. Go to original source... Go to PubMed...
    13. Kucher N, Wallmann D, Carone A, et al. Incremental prognostic value of troponin I and echocardiography in patiens with acute pulmonary embolism. Eur Heart J. 2003; 24: 1651-1656. Go to original source... Go to PubMed...
    14. Tulevski II, Hirsch A, Sanson BJ, et al. Increased brain natriuretic peptide as a marker for right ventricular dysfunction in acute pulmonary embolism. Tromb Haemost. 2001; 86: 1193-1196. Go to original source... Go to PubMed...
    15. Ten Wolde M, Tulevski II, Mulder JW, et al. Brain natriuretic peptide as a predictor of averse outcome in patiens with pulmonary embolism. Circulation. 2003; 107: 2082. Go to original source... Go to PubMed...
    16. Kucher N, Printzen G, Doerhoefer T, et al. Low pro-brain natriuretic peptide levels predict benign clinical outcome in acute pulmonary embolism. Circulation 2003; 107: 2082-2084. Go to original source... Go to PubMed...
    17. Kucher N, Printzen G, Goldhaber SZ. Prognostic role for brain natriuretic peptide in acute pulmonary emboliím. Circulation 2003; 107: 2545-2547. Go to original source... Go to PubMed...
    18. Konstantinides S, Geibel A, Heusel G, et al. Heparin plus alteplase compared with heparin alone in patiens with submassive pulmonary embolism. Management Strategie and Prognosis of Pulmonary Embolism-3 Trial Investigators. N Engl J Med. 2002; 347: 1143-1150. Go to original source... Go to PubMed...
    19. Wan S, Quinlan DJ, Agnelli G, et al. Thrombolysis compared with heparin for the Initial treatment of pulmonary embolism: a meta-analysis of the randomized controlled trials. Circulation 2004; 110: 744-9. 20. Go to original source... Go to PubMed...
    20. Scridon T, Seridon C, Alavarez A, et al. Elevated troponin I plus right ventricular dysfunction in acute pulmonary embolism: a lethal combination. Circulation 2002; 106: II-560 (Abstract).
    21. Nass N, McConnell MV, Goldhaber SZ, et al. Recovery of regional right ventricular function after thrombolysis for pulmonary embolism. Am J Cardiol 1999; 83: 804-806. Go to original source... Go to PubMed...
    22. Wolfe MW, Lee RT, Feldstein ML, et al. Prognostic significance of right ventricular hypokinesis and perfusion lung scan defects in pulmonary emboliím. Am Heart J 1994;127:1371-5. Go to original source... Go to PubMed...
    23. Meignan M, Rosso J, Gauthier H et al. Systematic lung svane repeal a high frequency of silent pulmonary embolism in patients with proximal deep venous thrombosis. Arch Intern Med 2000; 160: 159-164. Go to original source... Go to PubMed...
    24. Widimský J, Malý J a kol.: Akutní plicní embolie a žilní trombóza. Praha, Triton 2002.

    Return to the content


    Interventional Cardiology

    Madam, Sir,
    please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
    Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

    I declare:

    1. that I have met the above instruction
    2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited

    No
    Yes

    If your statement is not true, please be aware
    that brings the risk of danger to their health or the health of others.