Interv Akut Kardiol. 2019;18(2):74-76 | DOI: 10.36290/kar.2019.022

Prognostic significance of liver enzymes in acute heart failure

Radek Pudil¹, Kateřina Berdnová¹, Miloš Tichý²

¹ 1. interní kardioangiologická klinika LF UK a FN Hradec Králové

² Ústav klinické biochemie a diagnostiky LF UK a FN Hradec Králové

Heart failure is associated with liver congestion, and acute decompensation may lead to further progression. These changes can result in liver dysfunction which is manifested by an increase in transaminases. The aim of the study is to assess the prognostic significance of elevated liver function parameters in patients with acute heart failure. In a group of 92 patients (66.2 ± 13.9 years), the relationship between bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP) and mortality was analyzed. The study showed that one-year mortality was significantly associated with an increase in AST (median (IQR): 1.15 (0.65–3.28) vs. 0.49 (0.41–0.90), p 0.01 ) and ALP (2.0 (1.78–2.66) vs. 1.75 (1.13–2.12), p 0.01). AST has also been shown to be a significant risk factor determining 30 day and one-year mortality rates (30 day mortality: HR = 3.9, 95 % CI: 1.19–12.76, p 0.02, 1 year mortality: HR = 3.31, 95 % CI: 1.35–8.1, p 0.008). The results of the study confirm an increase in transaminase levels in patients with heart failure and show an association of transaminase levels with mortality indicators.

Keywords: liver enzymes, acute heart failure, prognosis

Published: May 2, 2019  Show citation