Interv Akut Kardiol. 2019;18(1):8-11 | DOI: 10.36290/kar.2019.015

Vitamin D deficiency in patients with acute coronary syndrome

Elena Shytova, Larisa Mikhailova, Robert Bogachev, Anastasia Kozel, Vitaly Ankudovich, Ulyana Dobrynina

Immanuel Kant Baltic Federal University, University of Medicine, Kaliningrad, Russian Federation

Background: Recent studies have shown that the functions of vitamin D are abundant, including its impact on the development of coronary artery disease (CAD).

Aims: Assess the serum vitamin D level in patients with acute coronary syndrome and compare with a group of healthy volunteers.

Subjects and methods: It is a cross-sectional observational study. Study subjects are patients with acute coronary syndrome. Exclusion criteria are the presence of diabetes mellitus, autoimmune diseases and malignant tumors. The control group included subjects without any cardiac disorders. Between August 2017 and November 2017, 50 patients with ACS and 22 healthy volunteers were enrolled in our study. The mean age of the participants in the ACS cohort was 59.9 ± 7.7 years, with a predominance of males (70 %).

Results: In the vast majority of patients with ACS, vitamin D deficiency was found. A marked deficiency was seen in 78 %. Vitamin D deficiency was not observed in the control group, but insufficiency was detected in 64 %. According to coronary angiography results, almost a half of the patients (45 %) with ACS and vitamin D deficiency had multivessel CAD.

Conclusions: We have found in our limited observation that the overwhelming majority of patients with acute coronary syndrome have vitamin D deficiency, in contrast to the control group – individuals with no cardiovascular problems.

Keywords: vitamin D deficiency, acute coronary syndrome, coronary artery disease

Published: March 8, 2019  Show citation