Interv Akut Kardiol. 2017;16(3):110-112 | DOI: 10.36290/kar.2017.020

Biodegradable stents: an uncertain future

Michael Želízko
Klinika kardiologie IKEM, Praha

The introduction of coronary stents in 1986 change the practice of interventional cardiology since its inception in 1977. Furtherdevelopment lead to metallic drug eluting stents (DES) with improving mechanical properties, decreasing strut thickness and introducingdegradable polymer or nonpolymer, abluminal drug coating. Leaving metallic support lifelong have generated interesttowards biodegradable technology. These temporary biodegradable vascular supports, made of polymers or metal alloys with a drugcoating, have the potential to scaffold the artery to allow natural healing, and then biodegrade. The development of this technologyhas been slow, several biodegradable stents have entered into clinical trials. This article will review the status of biodegradable stentswith an analysis of the causes that lead to worse clinical outcomes with uncertain future as compared to metallic stents.

Keywords: coronary stents, drug eluting stents, biodegradable vascular scaffolds

Received: September 21, 2017; Accepted: October 16, 2017; Published: November 1, 2017  Show citation

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Želízko M. Biodegradable stents: an uncertain future. Interv Akut Kardiol. 2017;16(3):110-112. doi: 10.36290/kar.2017.020.
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References

  1. Tamai H, Igaki K, Kyo E, et al. Initial and 6-month results of biodegradable poly-l-lactic acid coronary stents in humans. Circulation 2000; 102: 399-404. Go to original source...
  2. Ormiston JA, Serruys PW, Regar E, et al. A bioabsorbable everolimus-eluting coronary stent system for patients with single de-novo coronary artery lesions (ABSORB): a prospective open-label trial. Lancet 2008; 371: 899-907. Go to original source...
  3. Capodanno D, Gori T, Nef H, et al. Percutaneous coronary intervention with everolimus-eluting bioresorbable vascular scaffolds in routine clinical practice: early and midterm outcomes from the European multicentre GHOST-EU registry. EuroIntervention 2015; 10: 1144-53. Go to original source... Go to PubMed...
  4. Serruys PW, Chevalier B, Dudek D, et al. A bioresorbable everolimus-eluting scaffold versus a metallic everolimuseluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions (ABSORB II): an interim 1-year analysis of clinical and procedural secondary outcomes from a randomised controlled trial. Lancet 2015; 385: 43-54. Go to original source...
  5. Serruys PW, Chevalier B, Sotomi Y, et al. Comparison of an everolimus-eluting bioresorbable scaffold with an everolimuseluting metallic stent for the treatment of coronary artery stenosis (ABSORB II): a 3 year, randomised, controlled, singleblind, multicentre clinical trial. Lancet 2016; 388: 2479-91. Go to original source...
  6. Gao R, Yang Y, Han Y, et al. Bioresorbable vascular scaffolds versus metallic stents in patients with coronary artery disease: ABSORB China trial. J Am Coll Cardiol 2015; 66: 2298-309. Go to original source...
  7. Kimura T, Kozuma K, Tanabe K, et al. A randomized trial evaluating everolimus-eluting Absorb bioresorbable scaffolds vs. everolimus-eluting metallic stents in patients with coronary artery disease: ABSORB Japan. Eur Heart J 2015; 36: 3332-42. Go to original source... Go to PubMed...
  8. Ellis SG, Kereiakes DJ, Metzger DC, et al. Everolimus-eluting bioresorbable scaffolds for coronary artery disease. N Engl J Med 2015; 373: 1905-15. Go to original source...
  9. Ellis SG, et al. Everolimus-eluting bioresorbable vascular scaffolds in patients with coronary artery disease: ABSORB III trial 2-year results. Presented at: ACC 2017; March 18, 2017, Washington, DC.
  10. Absorb IV Randomized Controlled Trial. https://clinicaltrials.gov/ct2/show/NCT02173379
  11. Abizaid A, Costa RA, Schofer J, et al. Serial Multimodality Imaging and 2-Year Clinical Outcomes of the Novel DESolve Novolimus-Eluting Bioresorbable Coronary Scaffold System for the Treatment of Single De Novo Coronary Lesions. JACC Cardiovasc Interv. 2016 Mar 28; 9(6): 565-74. Go to original source... Go to PubMed...
  12. Haude M, Ince H, Kische S et al. Sustained safety and clinical performance of a drug-eluting absorbable metal scaffold up to 24 months: pooled outcomes of BIOSOLVE-II and BIOSOLVE-III. EuroIntervention. 2017 Jul 20; 13(4): 432-439. Go to original source... Go to PubMed...




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