Interv Akut Kardiol. 2015;14(1):10-13

Pentraxin 3 and interleukin 18 in the course of acute myocardial infarction

Lucie Horáková¹, Radek Pudil¹, Ctirad Andrýs², Jan Vojáček¹

¹ I. interní kardioangiologická klinika, FN a LF HK, UK v Praze

² Ústav klinické imunologie a alergologie, FN a LF HK, UK v Praze

Aim: The rupture of atherosclerotic plaques is responsible for acute myocardial infarction with all its consequences. We have studied the

changes in concentrations of new two markers (PTX3, IL18) in the patients with myocardial infarction and their relation to myocardial

dysfunction.

Material and methods: This study includes 29 patients with acute myocardial infarction and we have investigated these markers: pentraxin

3 (PTX3), interleukin 18 (IL-18), high sensitive troponin (hsTnT) and glycogenphosphorylase BB (GPBB). Samples were taken on the day of

admission, after 24 hours and on the fourth or fifth day of hospitalization. Monitored parameters were analysed through Elisa method.

Results: Markers showed very early increase in concentration and reached its peak as early as 24 hours (IL-18 maximum 657 pg/ml,

median 311 pg/ml, PTX3 maximum 12.2 μg/ml, median 3.36 μg/ml). Both parameters can therefore be considered as early markers of

progression of atherosclerosis and the formation of unstable atherosclerotic plaque. But we didn´t show the relationship of these markers

to the extent of myocardial damage and the development of post-infarction left ventricular systolic dysfunction.

Keywords: atherosclerotic plaque, acute myocardial infarction, pentraxin 3, interleukin 18

Published: April 20, 2015  Show citation