Interv Akut Kardiol. 2013;12(3):150-152

Urapidil, a first-choice drug for severe hypertensive states

Tomáš Janota, Tomáš Zelinka

Kardio JIP, 3. interní klinika, VFN Praha

Urapidil is a peripheral α-blocker as well as a weak central 5-hydroxytryptamine receptor agonist. It reduces peripheral vascular resistance

without causing significant reflex tachycardia. It is very well tolerated. From the perspective of an intensive cardiologist, the intravenous

form is important. Having a rapid, almost immediate onset of action and a relatively rapid cessation of action, urapidil is designed for the

management of hypertensive emergencies. Given its high efficacy and parenteral administration, it is certainly suitable for all conditions

with a more severe resistant hypertension where enteral treatment is not possible, the efficacy of oral therapy is inadequate, and there

is a need for a very rapid onset of action and, at the same time, a risk of a too rapid or too major decrease in blood pressure. Urapidil is

an appropriate first-choice drug for nearly all hypertensive emergencies. However, it is often used without proper knowledge, which is

what the present article aims to refresh and complement.

Keywords: urapidil, hypertensive emergencies, hypertensive crisis

Published: May 15, 2013  Show citation