Interv Akut Kardiol. 2012;11(1):22-27

Indications for cardiac resynchronization therapy: recent large trials and analyses of specific subgroups of patients

Kamil Sedláček, Josef Kautzner
Klinika kardiologie IKEM, Praha

Cardiac resynchronization therapy has become an integral part of the therapy spectrum in patients with advanced heart failure. Guidelines

for cardiac resynchronization therapy issued by the Czech Society of Cardiology in 2008 were based on the preceding version of

European guidelines for the treatment of heart failure and cardiac resynchronization therapy. European guidelines have been updated

in 2010 after results of major randomized trials in patients with mild heart failure became available. In this article we compare individual

versions of the guidelines and discuss indications for cardiac resynchronization therapy in specific subgroups, such as patients with

permanent atrial fibrillation, narrow QRS, or elderly population with significant comorbidities.

Keywords: cardiac resynchronization therapy, heart failure, guidelines

Published: January 28, 2012  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Sedláček K, Kautzner J. Indications for cardiac resynchronization therapy: recent large trials and analyses of specific subgroups of patients. Interv Akut Kardiol. 2012;11(1):22-27.
Download citation

References

  1. Cleland JG, Daubert JC, Erdmann E, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 2005; 352: 1539-1549. Go to original source... Go to PubMed...
  2. Bristow MR, Saxon LA, Boehmer J, et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 2004; 350: 2140-2150. Go to original source... Go to PubMed...
  3. Bradley DJ, Bradley EA, Baughman KL, et al. Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trials. JAMA 2003; 289: 730-740. Go to original source... Go to PubMed...
  4. Abraham WT, Fisher WG, Smith AL, et al. Cardiac resynchronization in chronic heart failure. N Engl J Med 2002; 346: 1845-1853. Go to original source... Go to PubMed...
  5. Cazeau S, Leclercq C, Lavergne T, et al. Effects of multisite biventricular pacing in patients with heart failure and intraventricular conduction delay. N Engl J Med 2001; 344: 873-880. Go to original source... Go to PubMed...
  6. Moss AJ, Hall WJ, Cannom DS, et al. MADIT-CRT Trial Investigators. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med 2009; 361: 1329-1338. Go to original source... Go to PubMed...
  7. Tang AS, Wells GA, Talajic M, et al. Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators. Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med 2010; 363: 2385-2395. Go to original source... Go to PubMed...
  8. Táborský M, Kautzner J, Bytešník J, et al. Zásady pro implantace kardiostimulátorů, implantabilních kardioverterů-defibrilátorů a systémů pro srdeční resynchronizační léčbu 2009. Cor Vasa 2009; 51: 602-618. Go to original source...
  9. Vardas PE, Auricchio A, Blanc JJ, et al. European Society of Cardiology; European Heart Rhythm Association. Guidelines for cardiac pacing and cardiac resynchronization therapy. The Task Force for Cardiac Pacing and Cardiac Resynchronization Therapy of the European Society of Cardiology. Developed in collaboration with the European Heart Rhythm Association. Europace. 2007; 9: 959-998. Go to original source... Go to PubMed...
  10. Dickstein K, Cohen-Solal A, Filippatos G, et al. ESC Committee for Practice Guidelines (CPG). ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008: the Task Force for the diagnosis and treatment of acute and chronic heart failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur J Heart Fail 2008; 10: 933-989. Go to original source... Go to PubMed...
  11. Authors/Task Force Members, Dickstein K, Vardas PE, Auricchio A et al.; ESC Committee for Practice Guidelines (CPG), Vahanian A, Auricchio A, Bax J, et al. Document Reviewers, Tendera M, Anker SD, Blanc JJ, et al. 2010 Focused Update of ESC Guidelines on device therapy in heart failure: an update of the 2008 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC guidelines for cardiac and resynchronization therapy. Developed with the special contribution of the Heart Failure Association and the European Heart Rhythm Association. Eur Heart J 2010; 31: 2677-2687. Go to original source... Go to PubMed...
  12. Linde C, Abraham WT, Gold MR, et al. REVERSE (REsynchronization reVErses Remodeling in Systolic left vEntricular dysfunction) Study Group. Randomized trial of cardiac resynchronization in mildly symptomatic heart failure patients and in asymptomatic patients with left ventricular dysfunction and previous heart failure symptoms. J Am Coll Cardiol 2008; 52: 1834-1843. Go to original source... Go to PubMed...
  13. Daubert C, Gold MR, Abraham WT, et al. REVERSE Study Group. Prevention of disease progression by cardiac resynchronization therapy in patients with asymptomatic or mildly symptomatic left ventricular dysfunction: insights from the European cohort of the REVERSE (Resynchronization Reverses Remodeling in Systolic Left Ventricular Dysfunction) trial. J Am Coll Cardiol 2009; 54: 1837-1846. Go to original source... Go to PubMed...
  14. Stefan L, Sedláček K, Krýže L, et al. Super-response in CRT: pronounced benefit may be associated with less advanced heart silure. European Heart Journal 2010; 31 (Abstract Supplement ESC Congress 2010, Stockholm): 412.
  15. Baldasseroni S, De Biase L, Fresco C, et al. Italian Network on Congestive Heart Failure. Cumulative effect of complete left bundle-branch block and chronic atrial fibrillation on 1-year mortality and hospitalization in patients with congestive heart failure. A report from the Italian network on congestive heart failure (in-CHF database). Eur Heart J 2002; 23: 1692-1698. Go to original source... Go to PubMed...
  16. Dickstein K, Bogale N, Priori S, et al. Scientific Committee; National Coordinators. The European cardiac resynchronization therapy survey. Eur Heart J 2009; 30: 2450-2460. Go to original source... Go to PubMed...
  17. Steinberg JS. Desperately seeking a randomized clinical trial of resynchronization therapy for patients with heart failure and atrial fibrillation. J Am Coll Cardiol 2006; 48: 744-746. Go to original source... Go to PubMed...
  18. Gasparini M, Auricchio A, Regoli F, et al. Four-year efficacy of cardiac resynchronization therapy on exercise tolerance and disease progression: the importance of performing atrioventricular junction ablation in patients with atrial fibrillation. J Am Coll Cardiol 2006; 48: 734-743. Go to original source... Go to PubMed...
  19. Koplan BA, Kaplan AJ, Weiner S, Jones PW, Seth M, Christman SA. Heart failure decompensation and all-cause mortality in relation to percent biventricular pacing in patients with heart failure: is a goal of 100 % biventricular paging necessary? J Am Coll Cardiol 2009; 53: 355-360. Go to original source... Go to PubMed...
  20. Kamath GS, Cotiga D, Koneru JN, et al. The utility of 12lead Holter monitoring in patients with permanent atrial fibrillation for the identification of nonresponders after cardiac resynchronization therapy. J Am Coll Cardiol 2009; 53: 1050-1055. Go to original source... Go to PubMed...
  21. Khadjooi K, Foley PW, Chalil S, et al. Long-term effects of cardiac resynchronisation therapy in patients with atrial fibrillation. Heart 2008; 94: 879-883. Go to original source... Go to PubMed...
  22. Delnoy PP, Ottervanger JP, Luttikhuis HO, et al. Comparison of usefulness of cardiac resynchronization therapy in patients with atrial fibrillation and heart failure versus patients with sinus rhythm and heart failure. Am J Cardiol 2007; 99: 1252-1257. Go to original source... Go to PubMed...
  23. Gasparini M, Steinberg JS, Arshad A, et al. Resumption of sinus rhythm in patients with heart failure and permanent atrial fibrillation undergoing cardiac resynchronization therapy: a longitudinal observational study. Eur Heart J 2010; 31: 976-983. Go to original source... Go to PubMed...
  24. Wilson FN. Concerning the form of the QRS deflections of the electrocardiogram in bundle branch block. J Mount Sinai Hosp N Y 1941; 8: 1110.
  25. Bristow MR, Saxon LA, Boehmer J, et al. Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 2004; 350: 2140-2150. Go to original source... Go to PubMed...
  26. Yu CM, Lin H, Zhang Q, Sanderson JE. High prevalence of left ventricular systolic and diastolic asynchrony in patients with congestive heart failure and normal QRS duration. Heart 2003; 89: 54-60. Go to original source... Go to PubMed...
  27. Bleeker GB, Schalij MJ, Molhoek SG, et al. Frequency of left ventricular dyssynchrony in patients with heart failure and a narrow QRS complex. Am J Cardiol 2005; 95: 140-142. Go to original source... Go to PubMed...
  28. Achilli A, Sassara M, Ficili S, et al. Long-term effectiveness of cardiac resynchronization therapy in patients with refractory heart failure and "narrow" QRS. J Am Coll Cardiol 2003; 42: 2117-2124. Go to original source... Go to PubMed...
  29. Yu CM, Chan YS, Zhang Q, et al. Benefits of cardiac resynchronization therapy for heart failure patients with narrow QRS complexes and coexisting systolic asynchrony by echocardiography. J Am Coll Cardiol 2006; 48: 2251-2257. Go to original source... Go to PubMed...
  30. Chung ES, Leon AR, Tavazzi L, et al. Results of the Predictors of Response to CRT (PROSPECT) trial. Circulation 2008; 117: 2608-2616. Go to original source... Go to PubMed...
  31. Beshai JF, Grimm RA, Nagueh SF, et al. RethinQ Study Investigators. Cardiac-resynchronization therapy in heart failure with narrow QRS complexes. N Engl J Med 2007; 357: 2461-2471. Go to original source... Go to PubMed...
  32. Sedláček K, Černá D, Predovski MK, Marek T, Kautzner J. Prospective evaluation of echocardiographic dyssynchrony parameters for prediction of reverse remodeling in cardiac resynchronization therapy. Abstract presentation. ESC Congress, Paris, 2011.
  33. Strauss DG, Selvester RH, Wagner GS. Defining left bundle branch block in the era of cardiac resynchronization therapy. Am J Cardiol 2011; 107: 927-934. Go to original source... Go to PubMed...
  34. Klemm HU, Krause KT, Ventura R, et al. Slow wall motion rather than electricalconduction delay underlies mechanical dyssynchrony in postinfarction patiens with narrow QRS complex. J Cardiovasc Electrophysiol 2010; 21: 70-77. Go to original source... Go to PubMed...
  35. Lehmann MH, Aaronson KD. CRT-D therapy in heart failure: how much do NYHA class IV patients benefit? J Cardiovasc Electrophysiol 2006; 17: 491-494. Go to original source... Go to PubMed...
  36. van Bommel RJ, Bax JJ, Abraham WT, et al. Characteristics of heart failure patients associated with good and poor response to cardiac resynchronization therapy: a PROSPECT (Predictors of Response to CRT) sub-analysis. Eur Heart J 2009; 30: 2470-2477. Go to original source... Go to PubMed...
  37. de Sisti A, Toussaint JF, Lavergne T, et al. Determinants of mortality in patiens undergoing cardiac resynchronization therapy: baseline clinical, echocardiographic, and angioscintigraphic evaluation prior to resynchronization. Pacing Clin Electrophysiol 2005; 28: 1260-1270. Go to original source... Go to PubMed...
  38. Herweg B, Ilercil A, Cutro R, et al. Cardiac resynchronization therapy in patients with end-stage inotrope-dependent class IV heart failure. Am J Cardiol 2007; 100: 90-93. Go to original source... Go to PubMed...
  39. Hochleitner M, Hörtnagl H, Ng CK, Hörtnagl H, Gschnitzer F, Zechmann W. Usefulness of physiologic dual-chamber pacing in drug-resistant idiopathic dilated cardiomyopathy. Am J Cardiol 1990; 66: 198-202. Go to original source... Go to PubMed...
  40. Kron J, Aranda JM Jr, Miles WM, et al. Benefit of cardiac resynchronization in elderly patients: results from the Multicenter InSync Randomized Clinical Evaluation (MIRACLE) and Multicenter InSync ICD Randomized Clinical Evaluation (MIRACLE-ICD) trials. J Interv Card Electrophysiol 2009; 25: 91-96. Go to original source... Go to PubMed...
  41. Foley PW, Chalil S, Khadjooi K, Smith RE, Frenneaux MP, Leyva F. Long-term effects of cardiac resynchronization therapy in octogenarians: a komparative study with a younger population. Europace 2008; 10: 1302-1307. Go to original source... Go to PubMed...
  42. Delnoy PP, Ottervanger JP, Luttikhuis HO, et al. Clinical response of cardiac resynchronization therapy in the elderly. Am Heart J 2008; 155: 746-751. Go to original source... Go to PubMed...
  43. António N, Lourenço C, Teixeira R, et al. Cardiac resynchronization therapy is effective even in elderly patients with comorbidities. J Interv Card Electrophysiol 2010; 27: 61-68. Go to original source... Go to PubMed...




Interventional Cardiology

Madam, Sir,
please be aware that the website on which you intend to enter, not the general public because it contains technical information about medicines, including advertisements relating to medicinal products. This information and communication professionals are solely under §2 of the Act n.40/1995 Coll. Is active persons authorized to prescribe or supply (hereinafter expert).
Take note that if you are not an expert, you run the risk of danger to their health or the health of other persons, if you the obtained information improperly understood or interpreted, and especially advertising which may be part of this site, or whether you used it for self-diagnosis or medical treatment, whether in relation to each other in person or in relation to others.

I declare:

  1. that I have met the above instruction
  2. I'm an expert within the meaning of the Act n.40/1995 Coll. the regulation of advertising, as amended, and I am aware of the risks that would be a person other than the expert input to these sites exhibited


No

Yes

If your statement is not true, please be aware
that brings the risk of danger to their health or the health of others.