Interv Akut Kardiol. 2012;11(1):18-21

Biomarkers of myocardial overload

Jan Krupička, Tomáš Janota

3. interní klinika 1. LF UK a VFN, Praha

The worldwide incidence of heart failure is steadily increasing over the past several decades, partly due to the population aging and improved

survival of patients with cardiovascular diseases. Therefore raises the importance of biochemical substances which would uncover

ongoing cardiac overload, enable the treatment monitoring and make care of the patients with heart failure more effective. According

to results of many clinical trials, this task is fulfilled at most by natriuretic peptides which gradually become a part of standard clinical

practise. In patients with acute as well as chronic heart failure we frequently detect higher plasma levels of cardiac troponin which present

worse prognosis in this population. Nowadays newer biomarkers are emerging such as mid-regional pro-adrenomedullin, mid-regional

pro-atrial natriuretic peptide and receptors for interleukin 33, which could further improve the management of heart failure patients.

Keywords: biological markers, heart failure, natriuretic peptides, adrenomedullin, dyspnea

Published: January 28, 2012  Show citation