Interv Akut Kardiol. 2010;9(3):147-150
Using of trimetazidine in percutaneous coronary interventions and coronary artery bypass grafting
- Kardiocentrum, Kardiochirurgická klinika LF UK a FN v Hradci Králové
Trimetazidine is a selective inhibitor of 3-ketoacyl-coenzyme A-thiolase. After its administration during hypoxia β-oxidation of free fatty
acid is blocked with metabolic switch in favour of glucose oxidation. During glucose oxidation less oxygen is consumed for production
of one molecule of adenosine triphosphate. As a result, the cell acidosis and its consequences are attenuated. Studies with trimetazidine
during revascularization procedures, which support the favourable effect of trimetazidine on severity of ischemia, myocardial necrosis
and ischemic-reperfusion injury, are reviewed in this article.
Keywords: trimetazidine, percutaneous coronary intervention, aorto-coronary bypass, ischemia, ischemic-reperfusion injury
Published: June 1, 2010 Show citation
References
- Simoons ML, van den Brand M, Lincoff M, et al. Minimal myocardial damane dutiny coronary intervention is associated with impared outcome. Eur Heart J 1999; 20: 11-12-9.
Go to original source... 
Go to PubMed... - Lemos PA, Hoze A, Serruys PW. Reccurent angina after revascularization: an emerging problem for the clinician. Coron Artery Dis 2004; 15(suppl 1): S11-S15. Go to PubMed...
- Boucher FR, Hearse DJ, Opie LH. Effects of trimetazidin on ischemic contracture in isolated perfused rat hearts. J Cardiovasc Pharmacol 1994; 24: 45-49. Go to original source... Go to PubMed...
- Kantor PF, Lucien A, Kozak R, Lopaschuk GD. The antianginal drug trimatazidine shifts cardiac energy metabolism from fatty acid oxidation to glukose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl koenzyme A thiolase. Cirk Res 2000; 86: 580-588. Go to original source... Go to PubMed...
- Kober G, Pennaforte S, Buck T, Sievert H, Vallbracht C. Myocardial cytoprotection during percutaneous transluminal coronary angioplasty. Eur Heart J 1993; 14(suppl G): 6-11. Go to original source... Go to PubMed...
- Steg PG, Grollier G, Gallay P, et al. A randomized doubleblind trial of intravenous trimetazidine as adjunctive therapy to primary angioplasty for acute myocardial infarction. Int J Cardiol 2001; 77: 263-273. Go to original source... Go to PubMed...
- Poloński L, Dec I, Wojnar R, Wilczek K. Trimetazidine limits the effects of myocardial ischaemia during percutaneous coronary angioplasty. Curr Med Res Opin 2002; 18: 389-96. Go to original source... Go to PubMed...
- Labrou A, Yiannoglou G, Zioutas D, et al. The role of trimetazidine at PTCA procedure: does trimetazidine minimize myocardial damane dutiny PTCA? Eur Heart J 2005; 26: Abstr Suppl 40.
- Bonello L, Sbragia P, Amabile N, et al. Protective effect of an acute oral loding dose of trimetazidine on myocardial injury following percutaneous coronary intervention. Heart 2007; 93: 703-707. Go to original source... Go to PubMed...
- Ruzyllo W, Szwed H, Sadowski Z, et al. Efficacy of trimetazidine in patiens with recurrent angina: a subgroup analysis of the TRIMPOL II study. Curr Med Res Opin 2004; 20: 1447-1454. Go to original source... Go to PubMed...
- Tünerir B, Colak O, Alatas O, Besogul Y, Kural T, Aslan R. Measurement of troponin T to detect cardioprotective effect of trimetazidine during coronary artery bypass grafting. Ann Thorac Surg 1999; 68: 2173-2176. Go to original source... Go to PubMed...
- Fabiani JN, Ponzio O, Emerit I, et al. Cardioprotective effect of trimetazidine during coronary artery graft surgery. J Cardiovasc Surg (Torino) 1992; 33: 486-491. Go to PubMed...
- Iskesen I, Saribulbul O, Cerrahoglu M, et al. Trimetazidine reduces oxidative stress in cardiac surgery. Circ J 2006; 70: 1169-1173. Go to original source... Go to PubMed...