Interv Akut Kardiol. 2010;9(2):86-88

CURRENT OASIS-7 study

Ota Hlinomaz

I. interní kardioangiologická klinika, FN u sv. Anny v Brně

Studie Current Oasis-7 byla poprvé prezentována S. R. Mehtou na kongresu Evropské kardiologické společnosti v Barceloně v září 2009.

The CURRENT OASIS-7 study was first presented by S. R. Mehta at the European Society of Cardiology Congress in Barcelona in September

2009. It was a randomized, multicentre trial seeking the optimal dose of clopidogrel and aspirin in patients with acute coronary

syndrome who were intended for early coronary angiography. A total of 25,087 patients were randomized in a 2 × 2 factorial design to

receive either double-dose or standard-dose clopidogrel and also low-dose or high-dose acetylsalicylic acid (ASA). The double dose of

clopidogrel administered to patients with acute coronary syndrome who received early percutaneous coronary intervention statistically

significantly reduced the rate of stent thrombosis, myocardial infarction and the primary composite endpoint of cardiovascular death,

myocardial infarction and stroke. This was counterbalanced by a higher incidence of major and severe bleeding. Cardiovascular mortality

did not depend on the dose of clopidogrel. The dose of ASA had no effect on the efficacy and safety of treatment. The study has not

yet been published in any major medical journal.

Keywords: acute coronary syndrome, clopidogrel, acetylsalicylic acid, stent thrombosis, bleedin

Published: April 1, 2010  Show citation