Interv Akut Kardiol. 2008;7(5):193-199

Novel biomarkers in acute cardiology

Jiří Kettner

Klinika kardiologie, Institut klinické a experimentální medicíny, Praha

Atherosclerosis is currently regarded as a dynamic process originating from endothelial dysfunction to plaque initiation, plaque progression, and finaly to the developement of plaque. Rupture or erosion of vulnerable plaques with subsequent trombus formativ is responsible for the development of acute ischemic event. Despite a substantial advances in the treatment of a acute coronary syndromes (ACS) over the past several years, the subset of patients developing LV remodelation and dysfunction with high risk for mortality or development of heart failure. The identification of high-risk patients with vulnerable plaques in coronary arteries before an acute event and patients with evolving myocardial dysfunction, remains a major challenge.

It is aim of this overview to summarize current knowledge on several novel biomarkers and their potential for risk stratification of patients with ACS, early detection of myocardial dysfunction and possible monitoring of therapy in the future.

Keywords: cardiac biomarkers, vulnerable plaque, acute coronary syndrome, LV remodelation, heart dysfunction

Published: December 20, 2008  Show citation