Interv Akut Kardiol. 2005;4(3):154-158
NEW DATA ON CLOPIDOGREL - THE CLARITY-TIMI 28, COMMIT-CCS2 AND ARMYDA-2 TRIALS
- I. interní kardioangiologická klinika FN u sv. Anny v Brně
Two new trials (CLARITY and COMMIT) have brought new data on the role of clopidogrel in treatment of patients with ST-elevation-myocardial infarction (STEMI). The ARMYDA-2 trial is concerned with optimalization of clopidogrel loading dose before intervention. In the CLARITY trial, the addition of clopidogrel to aspirin plus thrombolysis improved the patency rate of the infarct-related artery and reduced ischaemic complications in STEMI patients. The COMMIT trial has shown a positive effect of early administered clopidogrel on mortality of STEMI patients. In the ARMYDA-2 trial, pretreatment with a 600 mg loading dose of clopidogrel 4 to 8 hours before coronary intervention significantly reduced periprocedural MI as compared to the conventional 300 mg dose. All trials confirmed the safety of clopidogrel in relation to bleeding.
Keywords: Key words: clopidogrel, myocardial infarction, mortality, coronary intervention.
Published: January 1, 2006 Show citation
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