Interv Akut Kardiol. 2005;4(1):33-37

CONTRAST-INDUCED NEPHROPHATY TODAY (FENOLDAPAM DID NOT SUCCEED IN CONTRAST STUDY)

Katarína Lacová

Nemocnice Třebíč

Contrast nephropathy (CN) is a common cause of renal dysfuntion after coronarography. CN is associated with increased morbidity and mortality, including the permanent impairment of renal function, short-term dialysis and extended hospitalization. This article discuss the incidence, definition, pathophysiology, risk factors, treatment of CN; provides an overview of proven preventive interventions. Analysis of risk factors; use of low – or isoosmolar contrast media (CM) in high-risk patients; application of small volumes CM; time delay in some groups of patients; hydratation; use of acetylcysteine; discontinue of diuretics, ACE inhibitors and non-steroidal anti-inflammatory medications 1 to 2 days before procedure are recommended in prevention of CN. Fenoldapam showed no reduction in the incidency of CN in the CONTRAST study (large randomised preventive trial).

Keywords: Key words: contrast nephropathy, contrast media, risk factors, prevention.

Published: January 1, 2006  Show citation